4-Methylmorpholine → HCID 72271122, compound

HRID 2380764Notes

Reaction equation

HRID 2380764 reaction equation
[C:1]1([CH2:7][C:8](=[N:12][NH:13][C:14]2[S:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:18]=2)[C:9](O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[N:26]1CCOCC1>COCCOC>[C:1]1([CH2:7][C:8](=[N:12][NH:13][C:14]2[S:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:18]=2)[C:9]([NH2:26])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 79724-MethylmorpholineHCID 73021162HCID 73021162, compound

Product 1

HCID 72271122HCID 72271122, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To a solution of 3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid (4b) (1.0 mmol, 337 mg) in DME (5 mL) at −15° C., were added NMM (1.1 mmol, 121 μL), then IBCF (1.1 mmol, 147 μL). Then, a solution of NH4OH concentrated was added and the mixture was stirred for 20 minutes. 5 mL of water was added and the precipitate was filtered and washed with H2O and hexane to give the desired product.

Workup

  1. concentrationThen, a solution of NH4OH concentrated
  2. additionwas added
  3. addition5 mL of water was added
  4. filtrationthe precipitate was filtered
  5. washwashed with H2O and hexane

Sources & evidence

ORD record
ord-c5fc334fa5cb4d1da34b272ca38a0175
Source dataset
uspto-grants-2012_09
Patent number
US08257931B2

Reaction notes

Loading…