Potassium Hydroxide → HCID 59364049, compound

HRID 2380765Notes

Reaction equation

HRID 2380765 reaction equation
C([O:3][C:4](=[O:26])[CH:5]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:6][NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:12]=1)C.[OH-].[K+].OS([O-])(=O)=O.[K+]>CCO.O>[CH2:19]([CH:5]([CH2:6][NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:12]=1)[C:4]([OH:26])=[O:3])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 516920Potassium bisulfateHCID 59364042HCID 59364042, compound

Product 1

HCID 59364049HCID 59364049, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2-Benzyl-3-(4-phenyl-thiazol-2-ylamino)-propionic ethyl ester (22r) (0.028 mmol, 10 mg) in EtOH (2 mL) and water (200 μL) is added KOH 1N solution (224 μL, 8 eq.). After 5 hours, the solution is neutralized with KHSO4 1N solution and lyophilized before purification.

Workup

  1. customlyophilized before purification

Sources & evidence

ORD record
ord-80affb7eb23e4bd3842fa7721b6694e5
Source dataset
uspto-grants-2012_09
Patent number
US08257931B2

Reaction notes

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