Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-(1-trityl-1H-imidazol-4-yl)-propylamine | HCID 68874852 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178430444 | HCID 178430444 | — |
Reaction Steps
3.2 g 2-(1-trityl-1H-imidazol-4-yl)-propylamine is suspended in aqueous HCl (1 N). After the addition of 2.9 mL formaldehyde the mixture is heated to 95° C. with stirring. After 5 h it is cooled to RT, suction filtered to remove the precipitate formed and the solvent is eliminated in vacuo. This crude product is used in the following reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08258129B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-e73142bd30874a93aca363f3d2483565 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
