Formaldehyde → HCID 178430444, compound

HRID 2380823Notes

Reaction equation

HRID 2380823 reaction equation
C([N:20]1[CH:24]=[C:23]([CH:25]([CH3:28])[CH2:26][NH2:27])[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH2:29]=O>Cl>[CH3:28][CH:25]1[CH2:26][NH:27][CH2:29][CH:24]2[N:20]=[CH:21][NH:22][CH:23]12

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 688748522-(1-trityl-1H-imidazol-4-yl)-propylamine

Product 1

HCID 178430444HCID 178430444, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
95 °C

Procedure

3.2 g 2-(1-trityl-1H-imidazol-4-yl)-propylamine is suspended in aqueous HCl (1 N). After the addition of 2.9 mL formaldehyde the mixture is heated to 95° C. with stirring. After 5 h it is cooled to RT, suction filtered to remove the precipitate formed and the solvent is eliminated in vacuo. This crude product is used in the following reaction step without further purification.

Workup

  1. temperatureAfter 5 h it is cooled to RT
  2. filtrationsuction filtered
  3. customto remove the precipitate
  4. customformed

Sources & evidence

ORD record
ord-e73142bd30874a93aca363f3d2483565
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

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