HCID 57489618, compound → 1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, phenylMethyl ester

HRID 2380825Notes

Reaction equation

HRID 2380825 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[O:17])[CH2:14][CH2:15]2)=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 57489618HCID 57489618, compound

Product 1

HCID 574896191-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, phenylMethyl ester

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

11.28 g benzyl 4-(4-nitro-phenyl)-piperazine-1-carboxylate are dissolved in 500 mL MeOH and combined with 1 g Raney nickel. The mixture is hydrogenated for 18 h at 5 bar H2 pressure. Then the mixture is filtered to remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid are added and the solvent is eliminated in vacuo.

Workup

  1. filtrationThen the mixture is filtered
  2. customto remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid
  3. additionare added

Sources & evidence

ORD record
ord-e35ae6c390ba43249dda4ccd9025cb33
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

Loading…