Hydrazine hydrate (1:1) → HCID 68716573, compound

HRID 2380833Notes

Reaction equation

HRID 2380833 reaction equation
F[C:2]1[CH:7]=[C:6]([I:8])[C:5]([F:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[F:9][C:5]1[C:6]([I:8])=[CH:7][C:2]([NH:11][NH2:12])=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 532492112,5-Difluoro-4-iodopyridine

Product 1

HCID 68716573HCID 68716573, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 2,5-difluoro-4-iodopyridine (1.35 g, 5.602 mmol) in ethanol (7 mL) was treated with hydrazine hydrate (2.75 mL) and the mixture was stirred at 50° C. for 19 hours. The mixture was concentrated in vacuum and the resulting solid triturated with water, filtered, rinsed with more water and dried to yield the title compound (0.57 g, 35%) that was used in the following steps without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuum
  2. customthe resulting solid triturated with water
  3. filtrationfiltered
  4. washrinsed with more water
  5. customdried

Sources & evidence

ORD record
ord-aa4189e27e8344e89ae2a460219cfa2e
Source dataset
uspto-grants-2012_09
Patent number
US08258122B2

Reaction notes

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