反应详情

温度

50 °C

A solution of 2,5-difluoro-4-iodopyridine (1.35 g, 5.602 mmol) in ethanol (7 mL) was treated with hydrazine hydrate (2.75 mL) and the mixture was stirred at 50° C. for 19 hours. The mixture was concentrated in vacuum and the resulting solid triturated with water, filtered, rinsed with more water and dried to yield the title compound (0.57 g, 35%) that was used in the following steps without further purification.

1. concentrationThe mixture was concentrated in vacuum
2. customthe resulting solid triturated with water
3. filtrationfiltered
4. washrinsed with more water
5. customdried