N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → tert-Butyl 1-(2-(3,5-difluoropyridin-2-yl)hydrazinyl)-2-methyl-1-oxopropan-2-ylcarbamate

HRID 2380839Notes

Reaction equation

HRID 2380839 reaction equation
[F:1][C:2]1[C:3]([NH:9][NH2:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.[C:11]([O:15][C:16]([NH:18][C:19]([CH3:24])([C:21](O)=[O:22])[CH3:20])=[O:17])([CH3:14])([CH3:13])[CH3:12]>>[F:1][C:2]1[C:3]([NH:9][NH:10][C:21](=[O:22])[C:19]([NH:18][C:16](=[O:17])[O:15][C:11]([CH3:14])([CH3:13])[CH3:12])([CH3:24])[CH3:20])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 211023053,5-Difluoro-2-hydrazinylpyridine

Product 1

HCID 68714361tert-Butyl 1-(2-(3,5-difluoropyridin-2-yl)hydrazinyl)-2-methyl-1-oxopropan-2-ylcarbamate

Procedure

This compound was prepared (66%) from 3,5-difluoro-2-hydrazinopyridine and N-(tert-butoxycarbonyl)-2-methylalanine following the experimental procedure described for the synthesis of Intermediate 21, step a.

Sources & evidence

ORD record
ord-f473e0b50a9e41cba1627851fb3bb644
Source dataset
uspto-grants-2012_09
Patent number
US08258122B2

Reaction notes

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