1,4-Dioxane hydrochloride → [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]amine

HRID 2380899Notes

Reaction equation

HRID 2380899 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([NH:18]C(=O)OC(C)(C)C)=[CH:15][CH:16]=3)[O:11][C:10]([CH3:27])([CH3:26])[C:9]=2[CH:28]=[CH2:29])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([NH2:18])=[CH:15][CH:16]=3)[O:11][C:10]([CH3:26])([CH3:27])[C:9]=2[CH:28]=[CH2:29])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59442986tert-butyl [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]carbamate

Product 1

HCID 59443070[4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]amine

Procedure

The compound obtained in (2) described above (182 mg) and 4N hydrochloric acid-dioxane solution (4 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound as a crude product.

Sources & evidence

ORD record
ord-3af655de56f14da3b31f3dd555b68783
Source dataset
uspto-grants-2012_09
Patent number
US08258131B2

Reaction notes

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