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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2380899Generated: October 30, 2026

1,4-Dioxane hydrochloride → [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]amine

https://huagongshe.com/reaction/2380899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
Reactanttert-butyl [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]carbamateHCID 59442986—
Product[4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]amineHCID 59443070—

Reaction Steps

The compound obtained in (2) described above (182 mg) and 4N hydrochloric acid-dioxane solution (4 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound as a crude product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258131B2
Source datasetuspto-grants-2012_09
ORD IDord-3af655de56f14da3b31f3dd555b68783
Source noteuspto-grants-2012_09