1,4-Benzenediamine, N,N,N'-trimethyl- → (2-Chloro-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine

HRID 2381008Notes

Reaction equation

HRID 2381008 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+]([O-])=O)[CH:8]=2)[N:3]=1.[CH3:16][N:17]([CH3:26])[C:18]1[CH:23]=[CH:22][C:21]([NH:24][CH3:25])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[N:11]=[C:10]([N:24]([C:21]2[CH:22]=[CH:23][C:18]([N:17]([CH3:16])[CH3:26])=[CH:19][CH:20]=2)[CH3:25])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 5915951,4-Benzenediamine, N,N,N'-trimethyl-HCID 127033662,4-Dichloro-6-nitroquinazoline

Product 1

HCID 11688214(2-Chloro-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine

Procedure

The title compound was prepared from 2,4-dichloro-6-nitro-quinazoline and N1,N1,N4-trimethylbenzene-1,4-diamine by a procedure similar to example 44. 1H NMR (CDCl3): 7.71 (m, 1H), 7.51-7.56 (m, 1H), 7.07 (m, 2H), 6.99 (m, 2H), 6.71 (m, 2H), 3.59 (s, 3H), 3.01 (s, 6H).

Sources & evidence

ORD record
ord-d7bcdd348dd34b9bb534c4da71714c7e
Source dataset
uspto-grants-2012_09
Patent number
US08258145B2

Reaction notes

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