反应详情

A solution of 7-benzyloxy-4-(4-chloro-2-fluoroanilino)-6-methoxyquinazoline hydrochloride (892 mg, 2 mmol) in TFA (10 ml) was heated at reflux for 50 minutes. After cooling, the mixture was poured onto ice. The precipitate was collected by filtration, dissolved in methanol (10 ml) and basified to pH11 with aqueous ammonia. After concentration by evaporation, the solid product was collected by filtration, washed with water then ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline as a yellow solid (460 mg, 72%).

1. temperatureat reflux for 50 minutes
2. temperatureAfter cooling
3. additionthe mixture was poured onto ice
4. filtrationThe precipitate was collected by filtration
5. dissolutiondissolved in methanol (10 ml)
6. concentrationAfter concentration
7. customby evaporation
8. filtrationthe solid product was collected by filtration
9. washwashed with water
10. dry with materialether and dried under vacuum