HRID2381120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7991

Pentanoic acid

C5H10O2

结构：FC(F)(F)c1nnc2n1N=C(N1CCC(c3ccc(OCCN4CCNCC4)cc3)CC1)CC2

HCID68503084

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N1CCN(CCOc2ccc(C3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID46893980

未命名化合物

收率 36%

PROCEDURE

实验过程

Obtained in 36% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[2-(piperazin-1-yl)ethoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine and pentanoic acid.

WORKUP

后处理

customObtained in 36% yield by an analogous method to Example 4.1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31e782ba22264fb6a791c874f28682a7
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258140B2
来源说明: uspto-grants-2012_09

反应 SMILES

[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([CH:16]3[CH2:21][CH2:20][N:19]([C:22]4[CH2:23][CH2:24][C:25]5[N:26]([C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=5)[N:27]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:35](O)(=[O:40])[CH2:36][CH2:37][CH2:38][CH3:39]>>[C:35]([N:4]1[CH2:3][CH2:2][N:1]([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([CH:16]3[CH2:21][CH2:20][N:19]([C:22]4[CH2:23][CH2:24][C:25]5[N:26]([C:28]([C:31]([F:33])([F:34])[F:32])=[N:29][N:30]=5)[N:27]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:40])[CH2:36][CH2:37][CH2:38][CH3:39]