HRID2381122

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7991

Pentanoic acid

C5H10O2

结构：FC(F)(F)c1nnc2n1N=C(N1CCC(c3ccc(OCCCN4CCNCC4)cc3)CC1)CC2

HCID68502359

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N1CCN(CCCOc2ccc(C3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID46892043

未命名化合物

收率 66%

PROCEDURE

实验过程

Obtained in 66% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[3-(piperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine and pentanoic acid.

WORKUP

后处理

customObtained in 66% yield by an analogous method to Example 4.1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e867f47795f465ca3c21d24b6f7b58a
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258140B2
来源说明: uspto-grants-2012_09

反应 SMILES

[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23]4[CH2:24][CH2:25][C:26]5[N:27]([C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][N:31]=5)[N:28]=4)[CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:36](O)(=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40]>>[C:36]([N:4]1[CH2:3][CH2:2][N:1]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[CH:13][C:14]([CH:17]3[CH2:18][CH2:19][N:20]([C:23]4[CH2:24][CH2:25][C:26]5[N:27]([C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][N:31]=5)[N:28]=4)[CH2:21][CH2:22]3)=[CH:15][CH:16]=2)[CH2:6][CH2:5]1)(=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40]