Pentanoic Acid → 6-(4-{4-[3-(4-Pentanoylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

HRID 2381122Notes

Reaction equation

HRID 2381122 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23]4[CH2:24][CH2:25][C:26]5[N:27]([C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][N:31]=5)[N:28]=4)[CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:36](O)(=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40]>>[C:36]([N:4]1[CH2:3][CH2:2][N:1]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[CH:13][C:14]([CH:17]3[CH2:18][CH2:19][N:20]([C:23]4[CH2:24][CH2:25][C:26]5[N:27]([C:29]([C:32]([F:35])([F:34])[F:33])=[N:30][N:31]=5)[N:28]=4)[CH2:21][CH2:22]3)=[CH:15][CH:16]=2)[CH2:6][CH2:5]1)(=[O:41])[CH2:37][CH2:38][CH2:39][CH3:40]

Participants

3

Reactant 2

HCID 7991Pentanoic AcidHCID 685023596-[4-[4-[3-(Piperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 468920436-(4-{4-[3-(4-Pentanoylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazineYield 66%

Procedure

Obtained in 66% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[3-(piperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine and pentanoic acid.

Workup

  1. customObtained in 66% yield by an analogous method to Example 4.1

Sources & evidence

ORD record
ord-3e867f47795f465ca3c21d24b6f7b58a
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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