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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2381122Generated: November 3, 2026

Pentanoic Acid → 6-(4-{4-[3-(4-Pentanoylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

https://huagongshe.com/reaction/2381122

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPentanoic AcidHCID 7991—
Reactant6-[4-[4-[3-(Piperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazineHCID 68502359—
Product6-(4-{4-[3-(4-Pentanoylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazineHCID 4689204366%

Reaction Steps

Obtained in 66% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[3-(piperazin-1-yl)propoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine and pentanoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258140B2
Source datasetuspto-grants-2012_09
ORD IDord-3e867f47795f465ca3c21d24b6f7b58a
Source noteuspto-grants-2012_09