Acetic Anhydride → HCID 69812924, compound

HRID 2381158Notes

Reaction equation

HRID 2381158 reaction equation
[F:1][C:2]([F:14])([F:13])[CH:3]([CH3:12])[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1.[C:15](OC(=O)C)(=O)[CH3:16].[H-].[H-].[H-].[H-].[Li+].[Al+3]>CN(C1C=CN=CC=1)C>[CH2:15]([NH:11][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH:3]([CH3:12])[C:2]([F:13])([F:14])[F:1])=[CH:10][CH:9]=1)[CH3:16]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 21226445Aluminium lithium hydrideHCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

Product 1

HCID 69812924HCID 69812924, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

This material was prepared from (rac)-4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine by, first a standard acetylation reaction (acetic anhydride, DMAP as base) followed by reduction with LiAlH4 using standard literature procedures.

Sources & evidence

ORD record
ord-63333dbf311a44768cc856197df199a9
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

Loading…