Dimethyl dicarbonate → HCID 69812006, compound

HRID 2381160Notes

Reaction equation

HRID 2381160 reaction equation
[F:1][C:2]([F:14])([F:13])[CH:3]([CH3:12])[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1.[C:15](OC(OC)=O)(OC)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C(Cl)Cl>[CH3:15][NH:11][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH:3]([CH3:12])[C:2]([F:13])([F:14])[F:1])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 3086Dimethyl dicarbonateHCID 21226445Aluminium lithium hydrideHCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

Product 1

HCID 69812006HCID 69812006, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This material was prepared from (rac)-4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine by, first an standard methoxycarbonylation reaction with dimethyl dicarbonate in methylene chloride (at RT and 12 h stirring) followed by reduction with LiAlH4 according to standard literature procedures.

Sources & evidence

ORD record
ord-d73912abed0543fb9fcad81c6a870449
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

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