4-(Trifluoromethoxy)aniline → HCID 69809673, compound

HRID 2381174Notes

Reaction equation

HRID 2381174 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:17])([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:18][C:19]([F:29])([F:28])[O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][C:11]([F:17])([C:14](=[O:16])[NH:25][C:24]2[CH:26]=[CH:27][C:21]([O:20][C:19]([F:18])([F:28])[F:29])=[CH:22][CH:23]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 210503971-(tert-Butoxycarbonyl)-4-fluoropiperidine-4-carboxylic Acid

Product 1

HCID 69809673HCID 69809673, compoundYield 68.9%

Procedure

In analogy to example 1 from 4-fluoro-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (0.565 g), synthesis described in WO2008/98977, and 4-trifluoromethoxy-aniline (0.405 g) there as obtained 4-fluoro-4-(4-trifluoromethoxy-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.64 g) as an off white solid. MS (ESI): 405.1 ([M-H]−).

Sources & evidence

ORD record
ord-7415eb8b8e664336afe4222e9284edb5
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

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