HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)aniline → HCID 69809673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-fluoropiperidine-4-carboxylic Acid | HCID 21050397 | — |
| Product | HCID 69809673 | HCID 69809673 | 68.9% |
Reaction Steps
In analogy to example 1 from 4-fluoro-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (0.565 g), synthesis described in WO2008/98977, and 4-trifluoromethoxy-aniline (0.405 g) there as obtained 4-fluoro-4-(4-trifluoromethoxy-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.64 g) as an off white solid. MS (ESI): 405.1 ([M-H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258158B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7415eb8b8e664336afe4222e9284edb5 |
| Source note | uspto-grants-2012_09 |