4-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline → HCID 51001322, compound

HRID 2381176Notes

Reaction equation

HRID 2381176 reaction equation
[F:1][C:2]1([C:18]([OH:20])=O)[CH2:7][CH2:6][N:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH2:4][CH2:3]1.[F:21][C:22]([F:34])([F:33])[CH:23]([CH3:32])[O:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=1>>[F:21][C:22]([F:33])([F:34])[CH:23]([CH3:32])[O:24][C:25]1[CH:26]=[CH:27][C:28]([NH:31][C:18]([C:2]2([F:1])[CH2:3][CH2:4][N:5]([S:8]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)(=[O:10])=[O:9])[CH2:6][CH2:7]2)=[O:20])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-anilineHCID 698103204-Fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid

Product 1

HCID 51001322HCID 51001322, compoundYield 10.3%

Procedure

This material was made in analogy to example 1 from 4-fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (0.15 g), (rac)-4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine (0.102 g) to give the desired (rac)-4-fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid [4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-amide (0.025 g) as an off-white solid. MS (ESI): 489.25 (MH+).

Sources & evidence

ORD record
ord-95ec9cf301794bea81b3594e7964673f
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

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