4,4-Dimethylpentanoic acid → HCID 51001572, compound

HRID 2381187Notes

Reaction equation

HRID 2381187 reaction equation
[F:1][C:2]([F:20])([F:19])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1.[CH3:21][C:22]([CH3:29])([CH3:28])[CH2:23][CH2:24][C:25](O)=[O:26]>>[F:20][C:2]([F:19])([F:1])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:25](=[O:26])[CH2:24][CH2:23][C:22]([CH3:29])([CH3:28])[CH3:21])[CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 142374,4-Dimethylpentanoic acidHCID 18072435N-[4-(Trifluoromethoxy)phenyl]piperidine-4-carboxamide

Product 1

HCID 51001572HCID 51001572, compoundYield 89%

Procedure

This material was prepared in analogy to example 8 step C) from piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide (0.144 g) and 4,4-dimethyl-pentanoic acid (0.065 g) to give the desired 1-(4,4-dimethyl-pentanoyl)-piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide (0.178 g) as an off-white solid. MS (ESI): 401.25 (MH+).

Sources & evidence

ORD record
ord-bd081acb33be4bc0b128fdf220e608a8
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

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