反应详情

温度

110 °C

A solution of 5-(2,6-difluoro-phenoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (92.3 mg, 0.30 mmol) in methanol (0.6 mL, 0.5M) was treated with a 6N aqueous hydrochloric acid solution (0.25 L, 1.2M). The reaction was heated at 110° C. for 1 h and then stood at 25° C. overnight. At this point, the reaction was charged with water (10 mL). The solids were crushed, filtered, rinsed, and dried in vacuo to afford 5-(2,6-difluoro-phenoxy)-2H-pyridazin-3-one (45.7 mg, 68%) as an off-white solid; 1H-NMR (400 MHz, DMSO-d6) δ ppm 5.91 (s, 1H), 7.25-7.43 (m, 2H), 7.43-7.57 (m, 1H), 8.11 (d, J=2.6 Hz, 1H), 13.10 (brs, 1H).

1. customThe solids were crushed
2. filtrationfiltered
3. washrinsed
4. customdried in vacuo