Trimethylsilylacetylene → HCID 68895269, compound

HRID 238154Notes

Reaction equation

HRID 238154 reaction equation
I[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[CH3:11][Si:12]([C:15]#[CH:16])([CH3:14])[CH3:13]>>[CH3:11][Si:12]([C:15]#[C:16][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2)([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 247282194-iodo-1H-indazole

Product 1

HCID 68895269HCID 68895269, compoundYield 57%

Procedure

In an adaption of GP 8a, 4-Iodo-1H-indazole (1.00 g, 4.10 mmol) was reacted with trimethylsilyl acetylene (0.61 mL, 4.30 mmol) at 90° C. for 5 h to give 498 mg (57%) of pure 4-(trimethylsilyl)ethynyl-1H-indazole.

Sources & evidence

ORD record
ord-5b1e1ccd67c843809abeb8ea12a9ccd5
Source dataset
uspto-grants-2014_02
Patent number
US08642611B2

Reaction notes

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