Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylenediamine → N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 14116871 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86636619 | 39.5% |
반응 단계
A solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (160 mg, 0.85 mmol), ethylenediamine (0.170 mL, 2.55 mmol) and triethylamine (0.100 mL, 0.72 mmol) in nBuOH (4 mL) was stirred at 70° C. for 4 h. It was then purified by HPLC to give N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a solid (71 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08258144B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-17ef466f1e5d4cadaacd1e6b09e9dcb7 |
| 출처 메모 | uspto-grants-2012_09 |