Ethylenediamine → N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 2381671노트

반응식

HRID 2381671 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.[CH2:12]([NH2:15])[CH2:13][NH2:14].C(N(CC)CC)C>C(O)CCC>[NH2:14][CH2:13][CH2:12][NH:15][C:4]1[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=[C:2]([Cl:1])[N:3]=1

참가 물질

5

반응물 3

HCID 3301EthylenediamineHCID 8471TriethylamineHCID 141168712,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 86636619N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine수율 39.5%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (160 mg, 0.85 mmol), ethylenediamine (0.170 mL, 2.55 mmol) and triethylamine (0.100 mL, 0.72 mmol) in nBuOH (4 mL) was stirred at 70° C. for 4 h. It was then purified by HPLC to give N-(2-aminoethyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a solid (71 mg).

후처리

  1. customIt was then purified by HPLC

출처 및 근거

ORD 기록
ord-17ef466f1e5d4cadaacd1e6b09e9dcb7
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258144B2

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