5-Bromo-2,4-dichloropyrimidine → HCID 44467242, compound

HRID 2381764Notes

Reaction equation

HRID 2381764 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14](F)=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[NH:23][C:22](=[O:27])[CH2:21][CH2:20]4)[N:10]=2)[CH2:5][CH2:4]1.[Br:28]C1C(Cl)=NC(Cl)=NC=1>>[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([Br:28])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[NH:23][C:22](=[O:27])[CH2:21][CH2:20]4)[N:10]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 44467019HCID 44467019, compound

Product 1

HCID 44467242HCID 44467242, compound

Procedure

The titled compound was synthesized analogously as compound 6-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one, by using 5-bromo-2,4-dichloropyrimidine. MS 431.4 and 433.3 (M+N, Br pattern); UV 222.3, 263.9 nm.

Sources & evidence

ORD record
ord-ce0bfb8a86a542adbf9a80ab847ece0b
Source dataset
uspto-grants-2012_09
Patent number
US08258144B2

Reaction notes

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