HCID 59179696, compound → HCID 59179651, compound

HRID 2381843Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[C:4]([N:12]2[CH:16]=[C:15]([CH2:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22]C=3)[N:14]=[N:13]2)[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].CC1N=C(N2C=C(CC(C3C=CC=CC=3)C)N=N2)SC=1C(OCC)=O>>[CH3:1][C:2]1[N:3]=[C:4]([N:12]2[CH:16]=[C:15]([CH2:17][CH2:18][C:19]3[CH:20]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:14]=[N:13]2)[S:5][C:6]=1[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 59179696HCID 59179696, compound

HCID 68493040HCID 68493040, compound

Product 1

HCID 59179651HCID 59179651, compoundYield 70%

Procedure

Following the procedure as described in Example 13, making variations as necessary to replace ethyl 4-methyl-2-(4-(3-phenylpropyl)-1H-1,2,3-triazol-1-yl)thiazole-5-carboxylate with ethyl 4-methyl-2-(4-(2-phenylpropyl)-1H-1,2,3-triazol-1-yl)thiazole-5-carboxylate, the title compound was obtained as a white solid in 70% yield: 1H NMR (300 MHz, CDCl3) δ 11.21 (s, 1H), 8.08 (s, 1H), 7.31-7.21 (m, 5H), 3.19-3.05 (m, 4H), 2.75 (s, 3H); MS (ES+) m/z 315.3 (M+1).

Sources & evidence

ORD record: ord-5c4ad7ef8cce4ea1809a1114bca6884c
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08258160B2

Reaction notes

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