反应详情

Et3N (13.15 mmol) is added to a stirred solution of 2-phenyl-pyrimidine-5-carboxylic acid chloride (5.26 mmol) and hydrazine-acetic acid ethyl ester hydrochloride (5 mmol) in DCM (30 mL) at rt, and the mixture is stirred at rt for 5 h. The mixture is quenched with water and extracted with EtOAc (60 mL). The organic layer is washed with water (20 mL) and brine (15 mL), dried, filtered and concentrated in vacuo. The residue is purified by silical gel chromatography eluting with 5-50% EtOAc in heptane to afford [N′-(2-phenyl-pyrimidine-5-carbonyl)-hydrazino]-acetic acid ethyl ester (256 mg, 16%) as a solid. MS: 301 (M+H); 1H NMR (300 MHz, CDCl3): δ 1.35 (s, 3H), 4.20-4.40 (m, 4H), 4.56 (s, 2H), 7.54 (m, 3H), 8.53 (m, 2H), 9.24 (s, 2H).

1. customThe mixture is quenched with water
2. extractionextracted with EtOAc (60 mL)
3. washThe organic layer is washed with water (20 mL) and brine (15 mL)
4. customdried
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe residue is purified by silical gel chromatography
8. washeluting with 5-50% EtOAc in heptane