反应详情

温度

50 °C

A solution of 2-(2-pyridyl)-4-methyl-pyrimidine-5-carboxylic acid (215 mg, 1 mmol) and 3-ethyl-5-trifluoromethyl-indol-1-ylamine (228 mg, 1 mmol) in DMF (5 mL) is stirred at 50° C. for 1 h. The mixture is treated with DMTMM (276 mg, 1 mmol) and stirred at 50° C. for 2 h. The mixture is diluted with saturated aqueous Na2CO3 (5 mL) and stirred for 5 min. The precipitate is collected by filtration and dried in vacuo to afford 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethyl-indol-1-yl)-amide (235 mg, 55%). MS: 426 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 9.28 (s, 1H), 8.81 (d, 1H), 8.48 (d, 1H), 8.03 (m, 1H), 7.99 (s, 1H), 7.60 (m, 4H), 2.82 (q, 2H), 2.79 (s, 3H), 1.31 (t, 3H).

1. stirringstirred for 5 min
2. filtrationThe precipitate is collected by filtration
3. customdried in vacuo