反应详情

Isoamyl nitrite is added to a solution of 6-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (1 g) in DCM (15 mL) and heated to reflux overnight. The reaction mixture is concentrated in vacuo and the residue is purified by silica gel chromatography eluting with 10% EtOAc in heptane to give 6-Fluoro-4-nitroso-3,4-dihydro-2H-benzo[1,4]oxazine (0.83 g).

1. temperatureheated
2. temperatureto reflux overnight
3. concentrationThe reaction mixture is concentrated in vacuo
4. customthe residue is purified by silica gel chromatography
5. washeluting with 10% EtOAc in heptane