HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamyl Nitrite → 6-Fluoro-4-nitroso-3,4-dihydro-2H-benzo[1,4]oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | 6-Fluoro-3,4-dihydro-2H-1,4-benzoxazine | HCID 16244459 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Fluoro-4-nitroso-3,4-dihydro-2H-benzo[1,4]oxazine | HCID 86639382 | — |
Reaction Steps
Isoamyl nitrite is added to a solution of 6-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (1 g) in DCM (15 mL) and heated to reflux overnight. The reaction mixture is concentrated in vacuo and the residue is purified by silica gel chromatography eluting with 10% EtOAc in heptane to give 6-Fluoro-4-nitroso-3,4-dihydro-2H-benzo[1,4]oxazine (0.83 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258130B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c614821056c248cf81d3702b9e6e3c91 |
| Source note | uspto-grants-2012_09 |