反应详情

温度

40 °C

A solution of 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (490 mg, 2.28 mmol) and 3-ethyl-5-fluoropyrrolo[2,3-b]pyridin-1-ylamine (340 mg, 1.9 mmol) in DMF (6 mL) is stirred at 40° C. for 1 h. The mixture is treated with DMTMM (524 mg, 1.9 mmol) and stirred at 40° C. for 1 h. The mixture is diluted with saturated aqueous Na2CO3 (5 mL) and stirred for 5 min. The precipitate is collected by filtration and dried in vacuo to afford 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (3-ethyl-5-fluoro-pyrrolo[2,3-b]pyridin-1-yl)-amide (427 mg, 60%). MS: 377 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 11.94 (s, NH, 1H), 9.14 (s, 1H), 8.81 (d, 1H), 8.47 (d, 1H), 8.30 (s, 1H), 8.03 (m, 2H), 7.61 (m, 2H), 2.81 (s, 3H), 2.75 (q, 2H), 1.29 (t, 3H).

1. stirringstirred for 5 min
2. filtrationThe precipitate is collected by filtration
3. customdried in vacuo