Benzenepropanal → HCID 25122340, compound

HRID 2382158Notes

Reaction equation

HRID 2382158 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[N:22][C:23]=3[CH3:27])[N:18]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[C:28]1([CH2:34][CH2:35]C=O)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH3:27][C:23]1[N:22]=[CH:21][CH:20]=[C:19]2[C:24]=1[CH:25]=[CH:26][C:17]([NH:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][N:8]([CH2:1][CH2:35][CH2:34][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:9][CH2:10]1)=[N:18]2

Participants

3

Reactant 2

HCID 7707BenzenepropanalHCID 25122337HCID 25122337, compound

Product 1

HCID 25122340HCID 25122340, compound

Procedure

Compound 11 was prepared as described for compound 9, using 3-phenylpropionaldehyde in place of benzaldehyde. 1H NMR (CD3OD, 400 MHz) δ 8.20 (d, 1H, J=5.5 Hz), 8.10 (d, 1H, J=7.5 Hz), 7.10-7.35 (m, 6H), 6.82 (d, 1H, J=7.5 Hz), 3.60-3.70 (m, 2H), 2.50-2.90 (m, 15H), 2.30-2.45 (m, 2H), 1.75-1.90 (m, 2H). LCMS (EI) m/z 390 (M+1).

Sources & evidence

ORD record
ord-56526e73c1ad41ef975023766d6864d9
Source dataset
uspto-grants-2012_09
Patent number
US08258301B2

Reaction notes

Loading…