HCID 69029219, compound → HCID 1472673, compound

HRID 2382164Notes

Reaction equation

HRID 2382164 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)[CH3:2].[H][H]>C1COCC1.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)[CH3:2]

Participants

5

Reactant 2

HCID 69029219HCID 69029219, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 1472673HCID 1472673, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of intermediate (3) (0.0055 mol) in THF (50 ml) was hydrogenated with palladium on carbon (10%; 0.16 g) as a catalyst for 30 minutes at a temperature of 50° C. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated, yielding [1-(4-amino-phenyl)-piperidin-4-yl]-acetic acid ethyl ester (intermediate 4).

Workup

  1. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-e0123ab51023436d93597529e75ec7cd
Source dataset
uspto-grants-2012_09
Patent number
US08258304B2

Reaction notes

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