Hydrochloric Acid → HCID 68734580, compound

Participants

Reaction Steps

A mixture of tert-butyl 2-((R)-2-methyl-4-(2-phenylcyclohexyl)piperazin-1-yl)acetate (430 mg, 1.154 mmol) in 3 mL of 37% HCl was stirred at 50 C for 3 h. After LCMS showed complete conversion to the product, the solution was evaporated under high vacuum to dryness. The residue was crashed out of diethyl ether and dried to give 2-((R)-2-methyl-4-(2-phenylcyclohexyl)piperazin-1-yl)acetic acid dihydrochloride (440 mg, 97.9% yield) as an off white solid. MS (ESI, pos. ion) m/z: 317.2 (M+1).

Provenance & Evidence