Hydrochloric Acid → HCID 68734580, compound

HRID 2382181Notes

Reaction equation

HRID 2382181 reaction equation
[CH3:1][C@@H:2]1[CH2:7][N:6]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:5][CH2:4][N:3]1[CH2:20][C:21]([O:23]C(C)(C)C)=[O:22].[ClH:28]>>[ClH:28].[ClH:28].[CH3:1][C@@H:2]1[CH2:7][N:6]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:5][CH2:4][N:3]1[CH2:20][C:21]([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68736144HCID 68736144, compound

Product 1

HCID 68734580HCID 68734580, compoundYield 97.9%

Procedure

A mixture of tert-butyl 2-((R)-2-methyl-4-(2-phenylcyclohexyl)piperazin-1-yl)acetate (430 mg, 1.154 mmol) in 3 mL of 37% HCl was stirred at 50 C for 3 h. After LCMS showed complete conversion to the product, the solution was evaporated under high vacuum to dryness. The residue was crashed out of diethyl ether and dried to give 2-((R)-2-methyl-4-(2-phenylcyclohexyl)piperazin-1-yl)acetic acid dihydrochloride (440 mg, 97.9% yield) as an off white solid. MS (ESI, pos. ion) m/z: 317.2 (M+1).

Workup

  1. customthe solution was evaporated under high vacuum to dryness
  2. customdried

Sources & evidence

ORD record
ord-77a65fb03bba48d88be961200ee7d009
Source dataset
uspto-grants-2012_09
Patent number
US08258306B2

Reaction notes

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