Methylamine → HCID 67994669, compound

HRID 2382226Notes

Reaction equation

HRID 2382226 reaction equation
Cl[CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Br:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][NH2:20]>C(O)C>[CH3:19][NH:20][CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Br:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 67994431HCID 67994431, compound

Product 1

HCID 67994669HCID 67994669, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 1-B (1.31 g, 4.02 mmole) was dissolved in an aqueous solution of ethanol (40 ml) and methylamine (80 ml), and heated to reflux for 30 h. After cooling, the solution was extracted with chloroform (100 ml, twice), and an organic layer was decanted. The organic layer was dried over anhydrous sodium sulfate, and dried by evaporation under vacuum, to obtain the product as oil (1.28 g, 99.2%).

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 h
  3. temperatureAfter cooling
  4. extractionthe solution was extracted with chloroform (100 ml
  5. customtwice), and an organic layer was decanted
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customdried by evaporation under vacuum

Sources & evidence

ORD record
ord-4760cddb5dde42939dc019701837234e
Source dataset
uspto-grants-2012_09
Patent number
US08258331B2

Reaction notes

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