反应详情

温度

40 °C

A mixture of 1-acetyl-6-(bromoacetyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (10 mg), 2,4-difluorobenzylamine (6.0 mg) and N,N-diisopropylethylamine (10 l) in dioxane (2 ml) was stirred at 40° C. for 18 h. The reaction mixture was concentrated in vacuo. The residue was chromatographed on silicagel in dichloromethane/methanol=1/0=>95/5 (v/v) as eluent.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was chromatographed on silicagel in dichloromethane/methanol=1/0=>95/5 (v/v) as eluent