Hydrochloric Acid → HCID 23132148, compound

HRID 2382335Notes

Reaction equation

HRID 2382335 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[ClH:10]>[Pd]>[ClH:10].[NH2:1][C:2]1[NH:7][CH:6]([CH3:8])[CH2:5][CH:4]([CH3:9])[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 130212-Amino-4,6-dimethyl pyrimidine

Product 1

HCID 23132148HCID 23132148, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1 g 2-amino-4,6-dimethylpyrimidine was heated for 14 h in a hydrochloric acid environment (2 M HCl) with palladium on activated charcoal as a catalyst, with H2 fed in. Subsequent filtration, removal of the solvent and addition of diethyl ether yielded the 2-amino-4,6-dimethyl-1,4,5,6-tetrahydropyrimidine hydrochloride, which was recrystallized from i-propanol/diethyl ether and dried in a vacuum.

Workup

  1. filtrationSubsequent filtration, removal of the solvent and addition of diethyl ether

Sources & evidence

ORD record
ord-76c49d3725b04b588b8393ef470b7d98
Source dataset
uspto-grants-2012_09
Patent number
US08258501B2

Reaction notes

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