Perchloric Acid → HCID 67534618, compound

HRID 2382336Notes

Reaction equation

HRID 2382336 reaction equation
[NH2:1][C:2]1[NH:3][CH:4]([CH3:9])[CH2:5][CH:6]([CH3:8])[N:7]=1.Cl(O)(=O)(=O)=O.CO[CH:17](OC)[CH2:18][CH:19](OC)OC>>[CH3:8][CH:6]1[CH2:5][CH:4]([CH3:9])[N:3]2[CH:17]=[CH:18][CH:19]=[N:1][C:2]2=[N:7]1

Participants

4

Reactant 3

HCID 24247Perchloric AcidHCID 66019TetramethoxypropaneHCID 23132146HCID 23132146, compound

Product 1

HCID 67534618HCID 67534618, compound

Procedure

0.66 g 2-amino-4,6-dimethyl-1,4,5,6-tetrahydropyrimidine was refluxed to boiling point in a methanolic solution with the addition of perchloric acid with an equimolar amount of 1,1,3,3-tetramethoxypropane. Removing the solvent and coating the residue with a layer of diethyl ether yielded the 2,4-dimethyl-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidine hydroperchlorate, which was filtered off and dried in a vacuum.

Workup

  1. customRemoving the solvent and coating the residue with a layer of diethyl ether

Sources & evidence

ORD record
ord-72b8fe2209804c8b9edba0f1d00df4a0
Source dataset
uspto-grants-2012_09
Patent number
US08258501B2

Reaction notes

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