Hydrochloric Acid → HCID 135556069, compound

HRID 2382338Notes

Reaction equation

HRID 2382338 reaction equation
[N:1]1[C:2]2[N:3]([C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=3[N:9]=2)[CH:4]=[CH:5][CH:6]=1.[ClH:14]>[Pd]>[ClH:14].[NH:1]1[CH2:6][CH2:5][CH2:4][N:3]2[C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=3[N:9]=[C:2]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12826343Pyrimido[1,2-a]benzimidazole

Product 1

HCID 135556069HCID 135556069, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

0.602 g benzimidazo[1,2-a]pyrimidine hydroperchlorate was heated for 9 h in a hydrochloric acid solution (2 M HCl) with palladium on activated charcoal, with H2 fed in. Subsequent filtration, removal of the solvent and addition of diethyl ether yielded the 1,2,3,4-tetrahydro-benzimidazo[1,2-a]pyrimidine hydrochloride in the form of colorless crystals, which were recrystallized from ethanol.

Workup

  1. filtrationSubsequent filtration, removal of the solvent and addition of diethyl ether

Sources & evidence

ORD record
ord-83d34a053d1e4957a4b1cb9dd8c33fe2
Source dataset
uspto-grants-2012_09
Patent number
US08258501B2

Reaction notes

Loading…