Benzenesulfonamide, 3-amino- → HCID 20455860, compound

HRID 2382368Notes

Reaction equation

HRID 2382368 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:13](OC(Cl)(Cl)Cl)=[O:14]>O1CCOCC1>[N:1]([C:2]1[CH:3]=[C:4]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1)=[C:13]=[O:14]

Participants

4

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 10426Diphosgene

Product 1

HCID 20455860HCID 20455860, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a vigorously stirred solution of 3-aminobenzenesulphonamide (1 g, 5.8 mmol) in dry dioxane (25 ml) is added trichloromethyl chloroformate (1.72 g, 8.7 mmol) and the reaction mixture is heated to reflux for 3 hours. The solvent is removed in vacuo to yield the title product which is used without further purification.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureto reflux for 3 hours
  3. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-6526951d87fc4d3f9035118e930b0aa5
Source dataset
uspto-grants-2012_09
Patent number
US08258141B2

Reaction notes

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