HRID2382404

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：O=C(CO)N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccc(O)cc4)c4ccc(O)cc4)nc(N4CC[C@@H](NC(=O)NCc5cccc(O)c5)C4)nc32)[C@H](O)[C@@H]1O

HCID24862964

未命名化合物

PRODUCTS

生成物

结构：N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccc(O)cc4)c4ccc(O)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O

HCID86647548

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of Example 7 step 1 (3.45 g, 5.80 mmol) in methanol (7 ml) is treated with 4M HCl in dioxane (3 ml) and the reaction mixture is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between saturated sodium bicarbonate solution and DCM. The organic portion is separated, dried (MgSO4) and concentrated in vacuo to afford the title compound.

WORKUP

后处理

customThe solvent is removed in vacuo
customthe residue is partitioned between saturated sodium bicarbonate solution and DCM
customThe organic portion is separated
dry with materialdried (MgSO4)
concentrationconcentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-14dbb417d0fe4b71ad2769c5e0f80918
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258141B2
来源说明: uspto-grants-2012_09

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:49]2[CH:54]=[CH:53][C:52]([OH:55])=[CH:51][CH:50]=2)[CH2:9][NH:10][C:11]2[N:19]=[C:18](N3CC[C@@H](NC(NCC4C=CC=C(O)C=4)=O)C3)[N:17]=[C:16]3[C:12]=2[N:13]=[CH:14][N:15]3[C@@H:37]2[CH2:41][C@H:40]([NH:42]C(=O)CO)[C@@H:39]([OH:47])[C@H:38]2[OH:48])=[CH:4][CH:3]=1.[ClH:56]>CO.O1CCOCC1>[NH2:42][C@H:40]1[CH2:41][C@@H:37]([N:15]2[CH:14]=[N:13][C:12]3[C:16]2=[N:17][C:18]([Cl:56])=[N:19][C:11]=3[NH:10][CH2:9][CH:8]([C:49]2[CH:54]=[CH:53][C:52]([OH:55])=[CH:51][CH:50]=2)[C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)[C@H:38]([OH:48])[C@@H:39]1[OH:47]