Potassium Carbonate → HCID 86647549, compound

HRID 2382409Notes

Reaction equation

HRID 2382409 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]1([CH:14]([C:62]2[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=2)[CH2:15][NH:16][C:17]2[N:25]=[C:24]([C:26](=[O:46])[NH:27][CH2:28][CH2:29][NH:30][C:31]([NH:33][CH:34]3[CH2:39][CH2:38][N:37]([C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=4)[CH2:36][CH2:35]3)=[O:32])[N:23]=[C:22]3[C:18]=2[N:19]=[CH:20][N:21]3[C@@H:47]2[CH2:51][C@H:50]([NH:52][C:53]([CH2:55][O:56]C(=O)C)=[O:54])[C@@H:49]([OH:60])[C@H:48]2[OH:61])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:37]1([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)[CH2:38][CH2:39][CH:34]([NH:33][C:31](=[O:32])[NH:30][CH2:29][CH2:28][NH:27][C:26]([C:24]2[N:23]=[C:22]3[C:18]([N:19]=[CH:20][N:21]3[C@@H:47]3[CH2:51][C@H:50]([NH:52][C:53](=[O:54])[CH2:55][OH:56])[C@@H:49]([OH:60])[C@H:48]3[OH:61])=[C:17]([NH:16][CH2:15][CH:14]([C:62]3[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=3)[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:25]=2)=[O:46])[CH2:35][CH2:36]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86647550HCID 86647550, compound

Product 1

HCID 86647549HCID 86647549, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of acetic acid [(1S,2R,3S,4R)-4-(6-(2,2-diphenyl-ethylamino)-2-{2-[3-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-ureido]-ethylcarbamoyl}-purin-9-yl)-2,3-dihydroxy-cyclopentylcarbamoyl]-methyl ester trifluoroacetate (0.015 g, 16 μmol) in methanol (1 ml) is treated with potassium carbonate (0.01 g, 10 μmol) and the reaction mixture is allowed to stir at room temperature for 1 hour. The solvent is removed in vacuo and purification of the crude by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water—0.1% TFA) yields the title product. (MH+ 778.6)

Workup

  1. customThe solvent is removed in vacuo and purification of the crude by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water—0.1% TFA)

Sources & evidence

ORD record
ord-1ad98cf27f84444ab94eaa975355dd1d
Source dataset
uspto-grants-2012_09
Patent number
US08258141B2

Reaction notes

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