Acetic Anhydride → HCID 57703495, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluorophenyl acetic acid (0.928 g, 6.02 mmol), 3,5 dimethoxybenzaldehyde (1 g, 6.02 mmole), Ac2O (1 ml) and triethylamine (0.5 ml) was heated at 100° C. for 12 hours. Upon completion (as monitored by TLC using hexane-ethyl acetate (3:2), the reaction mixture was cooled to room temperature and concentrated HCL (5 ml) was added. The precipitate was dissolved in CH2Cl2 (100 ml), washed with 10% aqueous NaOH (3×50 ml) and the basic solution was acidified (PH-1) with concentrated HCL. After stirring, the precipitate was collected and dried to get the product (1.5 g, 82.87%).

Provenance & Evidence