Ethyl Acrylate → HCID 86647575, compound

HRID 2382522Notes

Reaction equation

HRID 2382522 reaction equation
[C:1](=[O:8])([O:3][CH2:4][CH2:5][CH2:6][OH:7])[NH2:2].[C:9]([O:13]CC)(=[O:12])[CH:10]=[CH2:11]>>[C:9]([OH:13])(=[O:12])[CH:10]=[CH2:11].[C:1](=[O:8])([O:3][CH2:4][CH2:5][CH2:6][OH:7])[NH2:2]

Participants

3

Reactant 2

HCID 8821Ethyl AcrylateHCID 1104068269493-47-6

Product 1

HCID 86647575HCID 86647575, compound

Procedure

250 g (comprising 0.9 mol of hydroxypropyl carbamate) were taken from the output from example 2 with a purity of 52.9%, and admixed with 2010 g (20.08 mol) of ethyl acrylate. At a temperature of 40° C., this mixture was conducted through a second jacketed glass column (length 40 cm, diameter 1.35 cm) charged with 12 ml of lipase (Novozym® 435) with the aid of a pump at a rate of 15 ml/h. The total reaction time was approx. 160 h, and the output in the reservoir vessel, the conversion and the purity were determined by means of GC analysis after various time intervals. The results are compiled in table 2.

Workup

  1. customAt a temperature of 40° C.
  2. additioncharged with 12 ml of lipase (Novozym® 435) with the aid of a pump at a rate of 15 ml/h

Sources & evidence

ORD record
ord-8170662ce21e4fcd990bb21c708334aa
Source dataset
uspto-grants-2012_09
Patent number
US08263370B2

Reaction notes

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