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A solution of phenylmagnesium bromide in ether (3 M, 2.3 mL) was added dropwise to a solution of 8-benzyl-8-aza-bicyclo[3.2.1]octan-3-one (1.0 g, 4.6 mmol) in THF (20 mL) that had been cooled to 0° C. The mixture was stirred for 3 hours and a solution of saturated aqueous ammonium chloride was added and the products extracted into diethyl ether, dried over sodium sulphate, filtered and the solvent removed by evaporation under vacuum. The residue was purified by flash chromatography on silica eluting with 10-30% ethyl acetate/hexane. The fractions containing the desired product were concentrated under vacuum to give the title compound (0.5 g) as an oil. LCMS m/z 294.4 [M+H]+. R.T.=2.59 min (Analytical Method 4).

1. extractionthe products extracted into diethyl ether
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. customthe solvent removed by evaporation under vacuum
5. customThe residue was purified by flash chromatography on silica eluting with 10-30% ethyl acetate/hexane
6. additionThe fractions containing the desired product
7. concentrationwere concentrated under vacuum