Acetyl chloride → HCID 68724463, compound

HRID 2382599Notes

Reaction equation

HRID 2382599 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH:10]([NH:13][S:14]([C:17]2[CH:22]=[C:21]([C:23]3[C:24]([CH3:30])=[N:25][C:26]([NH2:29])=[N:27][CH:28]=3)[CH:20]=[CH:19][C:18]=2[Cl:31])(=[O:16])=[O:15])[CH2:9][CH2:8]1>N1C=CC=CC=1>[NH2:29][C:26]1[N:25]=[C:24]([CH3:30])[C:23]([C:21]2[CH:20]=[CH:19][C:18]([Cl:31])=[C:17]([S:14]([NH:13][CH:10]3[CH2:9][CH2:8][CH:7]([CH2:6][NH:5][C:1](=[O:3])[CH3:2])[CH2:12][CH2:11]3)(=[O:16])=[O:15])[CH:22]=2)=[CH:28][N:27]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 68725603HCID 68725603, compound

Product 1

HCID 68724463HCID 68724463, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetyl chloride (0.045 ml, 0.066 mmol) is added to a stirred solution of N-(4-aminomethyl-cyclohexyl)-5-(2-amino-4-methyl-pyrimidin-5-yl)-2-chloro-benzenesulfonamide (Example 3-18) (0.090 g, 0.22 mmol) in dry pyridine (1 ml). After 30 min the reaction mixture is absorbed on silica and the product is purified by chromatography on silica, eluting with ethyl acetate to afford the title compound.

Workup

  1. customAfter 30 min the reaction mixture is absorbed on silica
  2. customthe product is purified by chromatography on silica
  3. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-ba2870fc1d8e4c1dba6a60dd412fff1f
Source dataset
uspto-grants-2012_09
Patent number
US08263585B2

Reaction notes

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