HCID 22629553, compound → HCID 417384, compound

HRID 238260Notes

Reaction equation

HRID 238260 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([O:20][CH3:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[CH3:21][O:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 22629553HCID 22629553, compound

Product 1

HCID 417384HCID 417384, compoundYield 108.8%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

4-Methoxy-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester (0.35 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 3 mL). The mixture was stirred for 1 hour and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound as a white solid (0.25 g). LCMS m/z 192.2[M+H]+. R.T.=1.96 min (Analytical Method 4).

Workup

  1. customthe solvent removed by evaporation under vacuum
  2. customThe solid was triturated from ether

Sources & evidence

ORD record
ord-002498204534478fbd3cd9f0742eac53
Source dataset
uspto-grants-2014_02
Patent number
US08642621B2

Reaction notes

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