Aniline → 5-bromo-2-chloro-N-(5-trifluoromethyl-pyridin-2-yl)-benzenesulfonamide

HRID 2382602Notes

Reaction equation

HRID 2382602 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:18])=[C:6]([S:8](NC2C=CC=CC=2)(=[O:10])=[O:9])[CH:7]=1.NC1C=CC=CC=1.[F:26][C:27]([F:36])([F:35])[C:28]1[CH:29]=[CH:30][C:31]([NH2:34])=[N:32][CH:33]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:18])=[C:6]([S:8]([NH:34][C:31]2[CH:30]=[CH:29][C:28]([C:27]([F:26])([F:35])[F:36])=[CH:33][N:32]=2)(=[O:10])=[O:9])[CH:7]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 687247275-Bromo-2-chloro-N-phenyl-benzenesulfonamide2×

Product 1

HCID 687257695-bromo-2-chloro-N-(5-trifluoromethyl-pyridin-2-yl)-benzenesulfonamide

Procedure

The titled compound is prepared as described for 5-Bromo-2-chloro-N-phenyl-benzenesulfonamide (Intermediate F, step 2), by replacing aniline in this procedure with 5-trifluoromethyl-pyridin-2-ylamine

Sources & evidence

ORD record
ord-5562a05665ca41c389253e0e1450a95c
Source dataset
uspto-grants-2012_09
Patent number
US08263585B2

Reaction notes

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