反应详情

To a stirring solution of 5-Bromo-2-chloroaniline (100 mg, 0.48 mmol) in DCM (5 ml) is added benzenesulfonyl chloride (280 mg, 202 ul, 1.58 mmol) and pyridine (195 ul, 2.42 mmol). The reaction mixture is stirred at room temperature for 18 hours. EtOAc (20 ml) is added and the reaction mixture is washed with 0.1 m HCl (20 ml), the phases are separated and the organic portion is washed with water (3×), dried over MgSO4, concentrated in vacuo and dried in a vacuum oven to afford the title compound.

1. washthe reaction mixture is washed with 0.1 m HCl (20 ml)
2. customthe phases are separated
3. washthe organic portion is washed with water (3×)
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. customdried in a vacuum oven